- Clyde and Helen Wu Professor of Chemical Systems Biology in the Columbia Initiative in Systems Biology (CISB), Department of Biochemistry and Molecular Biophysics, Department of Biomedical Informatics, Institute for Cancer Genetics;
- Founding Director and Chair, Columbia Initiative in Systems Biology which includes the Sulzberger Columbia Genome Center (CGC) and the Center for Computational Biology and Bioinformatics (C2B2), which is currently undergoing formal approval to department status;
- Director, Judy Sulzberger Columbia Genome Center (CGC)
- Associate Director, Herbert Irving Comprehensive Cancer Center (HICCC)
Dr. Califano’s interests reside in the assembly and interrogation of gene regulatory models for the elucidation of mechanisms presiding over cell physiology and their dysregulation in disease, with specific applications to cancer, stem cells, and neurodegenerative disease. His lab, which integrates both experimental and computational research, has pioneered the first genome-wide regulatory model of human cells and a variety of methods for the identification of master regulators of aberrant transformation and physiological differentiation/maturation events and their controlling genetic alterations. These approaches have led to the discovery of several new genes in glioma, leukemia, lymphoma, and prostate cancer that can be targeted pharmacologically to abrogate tumorigenesis. He has also pioneered network-based methods for the elucidation of mechanisms of action of drugs, drug synergy, and drug sensitivity.