Sean Luo, Psychiatry
Min Qian, Biostatistics
Kara Rudolph, Epidemiology  

Pharmacologic treatment of opioid use disorder (OUD) is complicated by the likely absence of a one-size-fits-all best approach; rather, “​optimal​”​ dose and dose adjustment are hypothesized to depend on person-level factors, including factors that change over time, reflecting how well the individual is responding to treatment. ​This team will use harmonized data from multiple existing clinical trials with natural variability in OUD medication dose adjustments over time to 1) learn optimal dosing strategies​,​ and 2) estimate the extent to which such optimal dosing strategies could reduce risk of treatment drop-out and relapse.