Dr. Miller is a leader in the exposome field, which strives to provide a systematic and comprehensive analysis of the non-genetic contributors to health and disease. He was the founding director of the HERCULES Exposome Research Center at Emory University, the first exposome-based research center in the U.S. He authored the first book on the topic, The Exposome: A Primer published by Elsevier. His research focuses on environmental drivers of neurodegeneration. His laboratory uses a variety of methods including transgenic mouse production, immunohistochemistry, neurotransmitter transport assays, high-resolution metabolomics, electrochemistry, and behavioral assays. His work is conducted in several experimental models from cultured neurons and C. elegans to mice and human studies.