In the Boldrini laboratory, research focuses on studying adult neurogenesis and angiogenesis in the human brain, which are mechanisms of structural plasticity occurring in mammals including humans, that are necessary for learning and coping, and for treatment response. We study stem cells and their progeny in the human adult brain and the molecular expression profile associated with the cellular changes, in the context of psychiatric, neurodevelopmental and neurodegenerative disorders, aging an stress conditions. This work generates an enormous amount of data that we need to analyze in concert with data deriving from the clinical information on the patient.